and Ozone Therapy
Oxygen is vital to
human cells while harmful to most pathogenic and infectious agents.
the metabolism, activates enzymes, detoxifies the
cells. White blood cells use hydrogen peroxide to kill bacteria, and with every
breath, we exchange oxygen with carbon dioxide inside every cell.
Extra oxygen can be
given through many ways. Hyperbaric oxygen chamber and use extra atmospheric
pressure to put oxygen in our body, Oxygen and Ozone can be directly injected
into joints, muscles, tissues, and abscesses, hydrogen peroxide can be infused
intravenously. Ozone and oxygen can also be mixed into our blood after it has
been taken out of the body in a bag. Another method is ozone and oxygen
infusion into the intestine and bladder.
When oxygen enters
into the tissues, special reactive oxygen species are formed, which stimulates
the immune system, alkalinize the blood, and sterilizes the cellular
compartment. These reactions can be useful in treating many chronic illnesses
and infections, autoimmune diseases could be modified by the reactive oxygen
species formed from ionic oxygen reactions.
different outcomes of patients with disc herniation treated either by
microdiscectomy, or by intradiscal ozone injection.
Acta Neurochir Suppl. 2005;92:139-42.
European Neurosurgical Institute, Treviso, Italy. email@example.com
Disc herniation with radiculopathy and chronic discogenic pain are the result of
degenerative processes. Treatment approach in face of this problem has largely
been debated in the last years. A number of reviews on surgical treatments in
the '80s and '90s have been published and various new techniques have been
introduced among which ozone discolysis is one non-invasive intradiscal
treatment method. In a 3-year follow-up period we have investigated the
different outcomes of 150 patients who received microdiscectomy and 150 patients
who received intradiscal ozone injection. In this series results are in favour
of discolysis for contained disc herniations and of microdiscectomy for large
migrated fragments with pain so severe that open surgery was obligatory. Apart
from this, our results with the two techniques are equivalent also concerning
mild neurological motor deficits.
Ozone chemonucleolysis in
non-contained lumbar disc herniations: a pilot study with 12 months follow-up.
Acta Neurochir Suppl. 2005;92:93-7.
Molino Lova R.
Unita Funzionale di Chirurgia Spinale c.d.c. Villanova, Florence, Italy. firstname.lastname@example.org
STUDY DESIGN: Prospective case series with six and twelve months follow up.
OBJECTIVE: To observe clinical and morphological results of the intradiscal
ozone chemionucleolysis in patients affected by non-contained lumbar disc
herniations. METHODS: 30 patients were included in the study on the base of
precise inclusion and exclusion criteria. The patients were followed on 6 and 12
months period by Visual Analogic Scale (VAS), Roland Morris Disability
Questionnaire (RMDQ) and Overall Patient Rating Scale (OPRS). Disc herniation
volume morphology was evaluated at 5 months by control MRI scanning. RESULTS:
Twenty-seven patients (90%) showed a statistically significant improvement in
pain (P < 0.001, Wilcoxon test) and function (P < 0.001, Wilcoxon test), on VAS
and RMDQ evaluation, respectively. The mean satisfaction with the treatment on
OPSR was 79.3%, with 24 patients referring satisfaction equal or greater than
80%. There were no major complications related to the procedure. CONCLUSIONS:
The results of this study indicate the ozone chemonucleolysis as a possibly
effective modality of treatment in patients affected by signs and symptoms of
non-contained lumbar disc herniations that have overpassed conservative measures
and have not yet fulfilled the indications for open surgical treatment.
Treatment of herniated lumbar
disc by intradiscal and intraforaminal oxygen-ozone (O2-O3) injection.
J Neuroradiol. 2004 Jun;31(3):183-9.
Neuroradiology OU, AORN Cardarelli, Naples, Italy.
MATERIAL: We report our experience between May 1996 and May 2003 with 2200
patients affected by low back pain or sciatica due to herniated disk treated by
intradiscal and intraforaminal oxygen-ozone injection. The patients received
medical and physical therapy before treatment for at least 2 months; the
patients with conus-cauda syndrome and hyperalgesic sciatica were excluded. We
never performed discography before the treatment that was performed under CT
guidance or fluoroscopy. CT provided monitoring of gas distribution in the disk
and epidural space. RESULTS: No side effects were recorded at short and
long-term follow-up. Clinical results were evaluated with the modified McNab
method showing an 80% success rate and 20% failure rate in 1750 patients
followed up to 6 months while the success rate dropped down at 75% and failure
increased at 25% in 1400 followed up to 18 months. CT showed reduction in the
size of the herniated disk in only 63% of the followed patients (420 patients).
The failure has been mostly related to: calcified herniated disk; spinal canal
stenosis; recurrent herniated disk with epidural fibrosis; small descending
herniated disk at the level of the lateral recess. Copyright 2004 Masson, Paris