Mesotherapy is a new and revolutionary treatment with multiple
applications for clinical medicine, performed personally by Dr Wong.
At GraceLifeMedicalCenter, a variety of nutraceutical,
herbal, homeopathic substances can be injected into the mesoderm to effect the desired clinical effects.
The mesoderm include cells
that make up the structure between the skin and internal organs, such as fat,
muscles, tendon, cartilage, joint
capsule, fibrous tissues. The acupuncture points are also located at the
By injecting selected
substances into the mesoderm, one can treat many illnesses including allergies,
asthma, chronic pain, arthritis, endocrine conditions and many chronic illnesses.
Mesolift is a process by which the injected substances
stimulate the laying down of new collagen underneath the skin, thus providing a
Mesoshape is a process by which a nutraceutical
substance is injected into the mesoderm to dissolve fat, thus shaping unwanted
fat from the body
What is Mesotherapy?
the French physician, Dr. Michel Pistor in 1952, mesotherapy is a non-surgical, relatively painless
injection technique with a broad range of applications. Mesotherapy
promotes the body’s circulatory, lymphatic, and immune system to create a
biological response and reverse abnormal physiology.
Mesotherapy is commonly practiced in France, where more
than 15,000 physicians utilize mesotherapy for the
care of their patients. In France, mesotherapy is actually taught in medical school. Mesotherapy is also practiced in many other countries
around the world, including Germany, Spain, Belgium, Columbia, Argentina and
Mesotherapy is an interventional injection technique that is
performed by licensed health care clinicians who are permitted to do
injections. Mesotherapy is a safe and
effective alternative for the treatment of cellulite, weight loss, hair loss
(alopecia), and face and neck rejuvenation. Unlike surgery, mesotherapy is virtually painless, requires no
post-operative recovery time, requires no heavy bandages or girdles, and no
anesthesia is necessary. While many surgical procedures require one to two
weeks of recovery, patients undergoing mesotherapy
have no interruptions to their daily life, while obtaining a natural cosmetic
rejuvenation. Mesotherapy involves the injection of
a customized mixture of vitamins, amino acids, and medications, placed just
millimeters under the skin into the problematic area. Just a “drop” of
solution is used at each injection site.
obtained with mesotherapy are dramatic. After
completing a series of mesotherapy treatments,
generally over a three month period of time, patients can notice improvement
in skin quality, less dimpling of the skin, and weight reduction including a loss of approximately ten pounds and one to two
clothing sizes. For those suffering from sagging skin and poor skin quality
of the face and neck, a “mesolift” may be
Uses for Mesotherapy
patients seeking fat loss, mesotherapy is a
revolutionary and essential tool. This is how it works: the biology of the
fat cell is modified by blocking the signals of fat accumulation and
simultaneously triggering the release of stored fat. Again, the desired area
of treatment can be patient specific, targeting your most problematic areas.
Additionally, a complete dietary and nutrient evaluation will help you
maintain your weight loss goals.
the majority of women over the age of 20. It is caused by poor circulation,
fat herniation, a weakening of connective tissues,
lymphatic congestion and hormonal imbalances. Cellulite is classified into
four stages, based upon its appearance while standing, laying, and pinching
the skin. Causing a dimpling and cottage cheese appearance of the skin,
cellulite is not a disease of excess weight. Mesotherapy
treatment is targeted to correct these problems by improving circulation,
strengthening connective tissues, and dissolving excess fat.
The loss of
hair, affects both men and women. Alopecia results from poor circulation,
nutritional imbalances, and the excess of a hormone known as DHT (dihydrotestosterone). Mesotherapy
can correct these problems, stimulating the body to naturally grow lost hair.
Face and Neck
Rejuvenation with Mesolift
sagging and wrinkling of the skin occurs from accumulation of fat, loss of
skin elasticity and excessive free radical damage. Using antioxidants and
amino acids, mesotherapy can remove fat from under
the neck, remove free radical damage, and tighten loose skin. The effects
rejuvenate the face, eyelids, and neck without the unnatural appearance and
painful recovery of surgical face lifting.
the abdomen, arms, back, legs and hands can be obtained with mesotherapy. Vitamins and amino acids are used to tighten
sagging skin while other agents are used to remove areas of fat, restoring a
more youthful and athletic appearance to the body’s contours.
Mesotherapy also has a variety of medicinal uses. Treatments
can benefit those patients suffering from muscle spasms, stress, insomnia,
carpal tunnel syndrome, fibromyalgia, infections,
RSD (reflex sympathetic dystrophy), and osteoarthritis, among other
conditions. Such a wide variety of conditions can be treated with this
technique as each treatment is formulated to meet each patient’s unique
problem. Mesotherapy is administered only into the
problematic area, avoiding the side effects of taking oral medications. For
example, the dosage of medication used to alleviate the pain of
osteoarthritis is approximately 1/50th of the comparable to the equivalent
oral dose taken over a one-week period.
face & neck rejuvenation (Mesolift)
hair loss / alopecia
sun damaged skin
carpal tunnel syndrome
Frequently Asked Questions
treatments are required?
the average patient requires eight to ten treatments. However thin people
with problem areas such as “love handles” or “saddlebags” may require less,
whereas obese individuals may require more. For acute conditions, such as
sports injuries, only one to three sessions may be needed.
What are the
are generally limited to bruising. The bruises usually fade within one week.
Can I go back
to work after the treatment?
procedure generally takes 30 minutes and requires no preparation or recovery
time. Furthermore, no heavy bandages or girdles are used.
of patients experience minimal discomfort with mesotherapy.
For those with lower pain thresholds, a numbing cream or painkillers can be
How long do
the benefits last?
areas will remain free of unwanted fat as long as the patient maintains a
healthy diet and exercise. Treatments for cellulite and for mesolift will require maintenance on a six month to one
year basis. Treatment of acute conditions generally do
not require maintenance treatments.
treatments are required before I see results?
It depends on
the patient’s body. Some patients see results after one treatment session
while others may require four to five treatments to begin to see results.
Often the patient’s clothing will become looser and friends and family will
tell the patient they appear thinner. However, mesotherapy
for fat reduction is more about losing inches than losing large amounts of
Is mesotherapy different from liposuction?
Yes, it is
very different. Besides involving no anesthesia and surgical risk, mesotherapy requires no recovery time. Mesotherapy also removes the fat from the fat cell
without destroying it. We believe this helps give mesotherapy
its natural appearance. Also, if you gain weight after having mesotherapy, the fat will simply return to the treated
area, unlike liposuction, where fat can start to occur in places that had
been thin in the past, such as the arms, neck, face and calves.
ISICO, Italian Scientific Spine Institute, Milan, Italy. email@example.com
AIM: Back pain is a highly frequent condition due to many causes, although
most of them cannot be established with certainty. It is also the current
clinical and scientific belief that sacroiliac joint syndrome can be a
specific low back pain cause. Nonetheless the existence of clinical tests
aimed at highlighting the responsibility for lumbar pain secondary to
sacroiliac dysfunction, it is not easy to diagnose it with either manual or
instrumental means. Moreover, uncertainty is diffuse when facing a correct
treatment for patients involved. The aim of this study was to verify, in
patients with acute or sub-acute low back pain and positive sacroiliac signs,
the efficacy of a stabilising therapy (orthosis and exercises, with previous
mesotherapy) directly targeted to sacroiliac dysfunction versus a symptomatic
usual care such as He-Ne laser therapy. METHODS: Over a period of 14 months,
we recruited 22 patients (10 females, mean age 44+/-11) with acute and
sub-acute low back pain and symptoms and signs suggesting a sacroiliac
dysfunction. They were randomised in a Group laser (GL), 11 patients treated
with He-Ne laser therapy targeting the sacroiliac region, and a Group
stabilisation (GS), 11 patients treated with mesotherapy, a
specific dynamic sacroiliac support (ILSA) and specific exercises. Outcome
criteria included VAS, and Mens and Laslett sacroiliac tests. RESULTS: Out of
449 acute and sub-acute low back pain out-patients, 22 (4.9%) had symptoms and
signs suggesting a sacroiliac dysfunction. A reduction of pain was achieved
only in the GS. All pain-provocation and stability tests were negative both
after the end of treatment and at the follow-up only in the GS. CONCLUSIONS: A targeted approach based on mesotherapy, a specific sacroiliac belt and
specific stabilizing exercises proved its efficacy in acute and sub-acute low
back pain patients with symptoms and signs suggesting a sacroiliac
dysfunction. As soon as it will be possible to identify particular
spine syndromes in the universe of non specific low back pain, there will also
be the possibility to employ specific therapies.
U.S. News & World Report, March 10, 2003
Mesotherapy promises to
target your fat spots with little hassle, little pain, and big results
BY KATY KELLY, U.S. News & World Report,
March 10, 2003
W hat if you could get
liposuction results without surgery? In a doctor’s office, over several short
visits, with only a smidgen of pain? What if like singer Roberta Flack, you
could say, “I lost 21/2 chins almost immediately”?
Flack is mad for mesotherapy, a French alternative treatment that’s
gaining popularity stateside. Patients receive 100 to 500 skin-deep
injections directly into trouble spots like hips or thighs. The shots usually
include tiny amounts of the emphysema drug aminophylline
and the heart medication isoproteranol, said to
melt fat, along with a homeopathic formula made of sweet clover. The
liquefied fat then “time-releases into the body,” where it is either used as
energy or excreted, says physician Lionel Bissoon.
… “I’m down from a size 16 to
a 10,” says Flack. “I have lost 32 pounds.” Losses come from the right
places. “It’s not about pounds,” says Marion Shapiro, a doctor who runs a mesotherapy clinic in West Orange, N.J. “It’s about inches.” After 10
sessions with Shapiro, Lisa Horowitz, 40, took 8 inches off her hips and
waist. Says Bissoon patient Linda Marshall, 62:
“I’m in a size 6, but suddenly I had a fat back.” After one treatment, she
adds, “I could see and feel a difference. Every time I’ve gone there’s less.
Now, it’s smooth and tight, the way it was when I was younger.”
Following is the research paper presented on Mesolift
at a Dermatological Conference by Dr Patricia Rittes,MD
The Use of Phosphatidylcholine for Correction of Lower Lid Bulging
Due to Prominent Fat Pads PatríciaGuedesRittes, MD ClínicaPatríciaRittes, São Paulo, Brazil
Presented at the 54th Brazilian Dermatology Congress, Belo Horizonte, Brazil, September 1999.
ROUND: Patients with
prominent periorbital fat pads often
complain of having a persistent "tired" look and seek treatment
from their dermatologist.
Objective: A non-surgical treatment of
Method of use: Thirty patients were
treated for prominent lower eylid fat pads with phosphatidylcholine injection. Pre- and posttreatment photographs were taken for long-term
Results: A marked reduction of the
lower eyelid fat pads was noted over the 2-year follow-up period. There were
Conclusion: The injection of phosphatidylcholine (250 mg/5ml) into the fat pads is a
simple office procedure that may postpone or even substitute for lower eyelid
INFRAORBITAL FAT PAD herniation results in a prominence of the lower eyelids,
causing patients to have a tired and aged appearance. These deformities
consist of skin, subcutaneous fat, orbicular muscle, and suborbicular
fat. Orbital fat exerts pressure both on the orbital septum and the orbicular
muscle, causing a bulge. What appers to be excess
skin is often merely the conversity caused by the
fat pads appearing under the skin. The precise
mechanism of this herniation is controversial.
deformity may be managed by surgical resection or reinsertion of the herniated
fat into the orbital cavity. (1-4) Continuous suture of the capsular palpebral fascia maintains it in its original anatomic
site. Herniation of the infraorbital
fat pad entity must be distinguished from periorbital
edema due to medical problems (such as angioneurotic
edema or fluid imbalance).
Phosphatidylcholine has been shown to reduce the
systemic levels of cholesterol and triglycerides. (5,6) Bobkova
et al. (7) showed that upon increasing phosphatidylcholine,
the cell membranes improved their receptor properies,
augmented their sensitivity to insulin, and accelerated lipolysis.
Phosphatidylcholine has also been employed
intravenously in patients with cardiac ischemia. (8) A marked reduction of atheromatous plaques withour a
reduction in plasma cholesterol occurs. Phosphatidylcholine
is a bile component and is responsible for the lipids’ emulsification from
the diet. (9) This article describes the use of phosphatidylcholine
injection into the infraorbital fat to reduce the
size of infraorbital fat pads.
Materials and Methods
study conformed to guidelines of th 1975
Declaration of Helsink . An informed consent was obtained from all individuals.
Preoperative evaluation included examining the size and location of the fat
pads. Baseline photographs were obtained. Patients were also examined for any
coexisting ocular pathology. The procedure was performed in an outpatient
setting with the patient seated. The skin of the lower lid was pulled
downward with the forefinger. Gentle pressure was applied over the globe for
better visualization of the fat pad. Using a 0.5 inch, 30-gauge needle, 0.4
ml of phosphatidylcholine
mg/5 ml) was injected into the infraorbital fat
pad. The medication was distributed among the there bulging periorbital fat pads (central, medial, and lateral) based
on the individual patient’s need.
were not utilized in this study.
patients with varying degrees of bulging fat pads were included in the study.
The patient population included 22 women and 8 men, with ages ranging from 30
to 70 years.
were given at 15-day intervals to allow for complete resolution of infraorbital swelling. Two patients received a total of
four aplications, 5 patients a total of three
applications, 12 patients a total of two applications, and 11 patients a
total of one application. The number of additional injections administered
was determined by the clinical response at the end of the 15-day period as
observed by the physician and patient.
improvement occurred in all patients. Pre-and postprocedure
photographs were utilized to document the changes (Figures 1 and 2). All
patients complained of mild burning following the injections, which typically
lasted about 15 minutes. Immediately following the injections, infiltrative
edema and local erythema were noted. Edema of the
entire lower lid was noted over the initial 6 hours and persisted for
approximately 72 hours.
Figure 1. A
71-year-old patient with prominent fat pads. B) Postprocedure
view after three injections of phosphatidylcholine.
Figure 2. A 55-year-old patient
with prominent fat pads. B) Postprocedure view
after four injections of phosphatidylcholine.
study offers a nonsurgical alternative for improving
"old-looking" eyes by reducing the prominence of bulging infraorbital fat pads through
phosphatidylcholine injection. Up until now, all options for treating
this entity have been surgically based. Proper patient selection is essential,
as this method only treats infraorbital
fat . Prominent infraorbital fat pads must be
distinguished from other periocular conditions,
including prominent malar folds and lax lower eyelid
phosphatidylcholine injection does not create scar
tissue, ectropion is not a risk. In our experience,
the postoperative results offered by phosphatidylcholine
injection were as natural in appearance as those obtained from surgical
procedures. Postoperative discomfort was also relative to surgery. In
addition, no recurrences of protruding infraorbital
fat pads were noted.
cosmetic results observed in this study were satisfactory from both the
patients’ and the dermatologists’ point of view. Patient selection is essencial for optimal results. This study provides a
simple, nonsurgical office-based procedure for
treating prominent infraorbital fat pads.
Acknowledgment I wish to thank Marcelo Gandelman, MD
for his help in editing this article and to A.S. Noel MD, French dermatologist
and pionner in the surgical excision of fat pads.
Presented at the 54th Brazilian Dermatology Congress, Belo Horizonte, Brazil, September 1999.
1. Parsa FD, Miyashiro MJ, Elahi E, Mirzai TM. Lower
eyelid hernia repair for palpebral bags: a
comparative study. PlastReconstrSurg 1998;102:7.
2. Sachs ME, Bosnick SL. Correction of true periorbital fat herniation in
cosmetic lower lid blepharoplaty. Aesthetic PlastSurg 1986;10:111.
3. Loeb R. Fat pad sliding and fat grafting for livelimp
lid depression. ClinPlastSurg 1981;8:757. 4. Hamra ST. The
role of orbital fat preservation in facial aesthetic surgery: a new concept. Clin Plast Surg 1996;23:17.
5 . Warembourg H, Jaillard J. Experimentation clinique du lipostabil dans le traitement
des angiopathies diabetiques. Lille Med
1968; XIII (suppl):721-3. 6 . N avder KP, Baraona E, Lieber C. Polyenyphosphatidylcholine decreases alcoholic hyperlipemia without affecting the alcoholinduced
rise of HDL cholesterol. Life Sei 1997;61:1907. 7 .Bobkova VI, Lokchina LI, Korsunsk BH, Tamamova GV. Metabolic effect of lipostabiforte.
Kardiologia 1989;29:57. 8 .Pogozheva AV, Bobkova SN, Samsonov ,MA, Vasilév. AV. Comparative evaluation of hypolipidemic effects of omega-3 polyunsaturated acids
and lipostabil. VoprPitan 1996;. 9 .Montgomery R,
Conway T. Bioquímica, 5th ed. 1994:249.
10. Farrior RT, Kassir
RR. Management of malar folds in blepharoplasty. Laringoscope
MD has indicated no significant interest with
commercial supportes. Address correspondence and reprint requests to: Patricia GuedesRittes, MD, Rua José do Patrocínio, 92 Aclimação, São
Paulo SP – Brazil, CEP
04108-13, or e-mail: firstname.lastname@example.org.
The Following is a research
article on the use of Mesotherapy in treating pain
and sports injuries
The Use of Mesotherapy in Sports Medicine
Bernard Montalvan, M.D.,
Jacques Parier, M.D., and Denis Laurens, M.D.,
French Tennis Federation, Stade Roland Garros, 2, Av. Gordon Bennett, 75016 Paris, France
Mesotherapy is a simple French therapeutic
technique that is widely used in Europe, although it is not well known in the US. It involves a local injection of
medication into the mesoderm, as close to the site of injury as possible. It
is used primarily for its analgesic, anti-inflammatory and muscle-relaxing
In sports medicine, it
can be of benefit to players with soft tissue injuries, who naturally aim to
be able to return to play at the earliest opportunity. Sports trauma is often
implicated in the treatment of soft tissue injuries. In most cases, the
congestive and inflammatory reaction of these tissues before healing
justifies taking pain-killing and anti-inflammatory medication.
The physician must not
ignore the possibility of recurring traumatism, however, which means that repeated
doses of medication will be needed and can be a cause of concern to the
prescribing doctor (for reasons of digestive tolerance, risk of allergies,
In the mesotherapeutic treatment of sports trauma, we currently
use the following products.
Procaine or Lidocaine, which
serve as vectors and improve the diffusion of the products (Lidocaine
for acute pathologies, Procaine for chronic pathologies)
An anti-inflammatory (Piroxicam)
A muscle relaxant (Thiocolchicoside)
These are injected into
the mesoderm around the area to be treated, using 4 mm 'Lebel'
needles. These can be used once only. The syringe can contain 1ml, 5ml or 10
ml according to the zone to be treated.
Procaine and Lidocaine
are Class IIIC products. Local injections are authorized only when
administration is medically justified. Where health regulations require, it
may be necessary to notify the authorities.
use mesotherapy Mesotherapy can be used for the following
Post-traumatic articular or peri-articular
inflammation, such as sequelae of a sprained
Inflammation of a tendon
plantar fasciitis or extensor carpiulnaristendinopathy
Muscle contraction: backache,
torticollis or lumbago
Spinal pain: facet syndrome.
The main two types of
Known allergy to one of the injectable substances
Poor skin condition.
The equipment must only be used once. The physician should wash his hands
with an antiseptic product and the skin around the area to be treated must be
disinfected with an iodised product.
The injection technique
is very simple. The needle penetrates at an angle of 60º up to the stop. On
average, 6 to 10 injection points are used, introducing a mean of 0.1 cc
mixture. If the zone to be treated is larger, more liquid is injected. After
treatment, no cream or ice should be applied and no massage should be used. A
dressing should be kept over the treated area for at least three hours.
Follow-up sessions can be
given on the third and seventh day after the first treatment. Efficiency
should then be evaluated.
Tolerance of the mesotherapy technique was examined
in a French national study of 2,839 patients. Overall, tolerance of the
technique was excellent. No anaphylactic or vagal
shock was observed. Neuro-vegetative reactions
(sweating, pallor) decreased in follow-up sessions. Side-effects essentially
involved the injection site. The table below shows the local effects. The
most frequent were pain at the injection points, which was frequent but
tolerable. Haematomas were small and disappeared in
a few days.
The French Mesotherapy Society is currently
conducting studies to explore and explain the method of action of this
therapeutic technique. Further details are available at the Society's
In our experience, mesotherapy can be a useful
technique for the treatment of sports trauma and micro-trauma. There are
virtually no adverse effects if the contra-indications are respected. The
doses of medicinal drug injected are tiny, which contributes to the good
general tolerance of the technique. However, the technique has not yet been
explored sufficiently and the lack of scientific validation is a frequent
handicap that we encounter in sports medicine and the fight against pain.